https://foldscout.com/ 2026-10-15T00:00:00Z Dr. Zhiqiang Chen https://foldscout.com/tools/ablang2/#2026-10-15 2026-10-15T00:00:00Z

BSD 3-Clause License. BSD 3-Clause LICENSE file in the repo; permissive, attribution and no-endorsement conditions only.

https://foldscout.com/tools/abodybuilder3/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0. LICENSE.txt in the repo is Apache-2.0; permissive, commercial use allowed.

https://foldscout.com/tools/alphafold2/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0 (code); CC BY 4.0 (model parameters). README's 'Model Parameters License' section states parameters are made available under CC BY 4.0, which replaced the earlier CC BY-NC 4.0 terms; attribution required. Some mirrored MSA databases carry their own CC BY-SA 4.0 terms.

https://foldscout.com/tools/alphafold3/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0 (code); 'AlphaFold 3 Model Parameters Terms of Use' (weights). Code is Apache-2.0, but the README states you may only use the model parameters if received directly from Google, and the weights Terms of Use make them available free of charge only for certain non-commercial uses, by or on behalf of non-commercial organisations. Commercial organisations cannot use the released weights under those terms.

https://foldscout.com/tools/alphafold-db/#2026-10-15 2026-10-15T00:00:00Z

Creative Commons Attribution 4.0 International (CC BY 4.0). The AlphaFold DB homepage and download page both state: 'Data is available for academic and commercial use, under a CC-BY-4.0 licence.'

https://foldscout.com/tools/alphaproteo/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0 covers only the input-preparation notebooks in the public repo; the model itself is unreleased. The only public artefact is the ap_trusted_testers repository, whose README describes a Colab that helps 'users of the AlphaProteo Trusted Tester Program' prototype requests and visualise target regions - an input builder, not the model. No weights, no inference code and no terms for commercial use of the designs are published, so rights are unverified.

https://foldscout.com/tools/anarci/#2026-10-15 2026-10-15T00:00:00Z

BSD 3-Clause style license (LICENCE file, 2019 Deane et al.). The LICENCE file contains BSD 3-Clause redistribution terms with no field-of-use restriction; GitHub's license detection also reports BSD-3-Clause.

https://foldscout.com/tools/anarcii/#2026-10-15 2026-10-15T00:00:00Z

BSD 3-Clause License. LICENCE file reported by the GitHub license API as BSD-3-Clause; permissive.

https://foldscout.com/tools/antifold/#2026-10-15 2026-10-15T00:00:00Z

BSD 3-Clause License (code and the released model weights). The repo LICENSE is BSD 3-Clause, and the README's model section links the weight download alongside an explicit 'License: BSD 3-Clause' line for those weights. One caveat read in the same README: an optional --esm_if1_mode runs ESM-IF1 weights instead, which carry Meta's own terms - check those if you use that flag.

https://foldscout.com/tools/autodock-vina/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0. Apache-2.0 LICENSE file in the repo; permissive.

https://foldscout.com/tools/bindcraft/#2026-10-15 2026-10-15T00:00:00Z

MIT License. Code is MIT, but the README states the installer installs PyRosetta, 'which requires a license for commercial purposes'. PyRosetta's own page confirms licensing is free for academic/non-profit and fee-based for commercial users. AlphaFold2 parameters it uses are CC BY 4.0, which does allow commercial use.

https://foldscout.com/tools/boltz-2/#2026-10-15 2026-10-15T00:00:00Z

MIT License. LICENSE file is MIT and the README states explicitly that all code and weights are MIT, freely usable for academic and commercial purposes.

https://foldscout.com/tools/boltzgen/#2026-10-15 2026-10-15T00:00:00Z

MIT License. The repo LICENSE is MIT, covering the code. The README documents automatic download of ~6 GB Boltz weights plus ESMFold2 weights but makes no license statement for those weights, so weight terms are unverified.

https://foldscout.com/tools/chai-1/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0. LICENSE file is Apache-2.0 and the README's Licence section states both code and model weights are Apache-2.0 and usable for academic and commercial purposes including drug discovery.

https://foldscout.com/tools/chai-2/#2026-10-15 2026-10-15T00:00:00Z

unverified (no public licence; access granted case-by-case under the vendor's Responsible Deployment policy). No licence text exists to read. The announcement says access is being opened to 'a number of academic and industry partners' via an early-access sign-up and granted under a Responsible Deployment policy. Terms for a commercial partner are not published, so rights are unverified. Listed here because it is widely cited and people ask - not because it is usable off the shelf.

https://foldscout.com/tools/chroma/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0 (code); Chroma Parameters License (weights, academic/non-profit only). The README's License section is explicit: code is Apache-2.0, but 'Chroma weights are freely available to academic researchers and non-profit entities' under the Chroma Parameters License, and anyone wanting to use the parameters 'beyond the scope of the rights granted in the License (including for commercial purposes)' is told to contact licensing@generatebiomedicines.com. So commercial use needs a negotiated licence from the company.

https://foldscout.com/tools/colabfold/#2026-10-15 2026-10-15T00:00:00Z

MIT License. MIT LICENSE file in the repo. The AlphaFold2 parameters it downloads are CC BY 4.0 per the AlphaFold README. Note the free public MSA server is intended for modest academic-scale use; heavy or commercial batch use should run a local MMseqs2 server.

https://foldscout.com/tools/diffab/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0. Apache-2.0 LICENSE in the repo; the trained checkpoints are distributed from the same repository with no separate terms. It does depend on antibody structure tooling, which you should licence-check separately.

https://foldscout.com/tools/esm-c/#2026-10-15 2026-10-15T00:00:00Z

MIT License. LICENSE.md in the repo is MIT (Copyright 2026 Chan Zuckerberg Biohub) and the README's Licenses section states the models are available under the MIT license. Note this differs from the earlier ESM3 non-commercial community license; verify the checkpoint you actually download.

https://foldscout.com/tools/esm2/#2026-10-15 2026-10-15T00:00:00Z

MIT License. The Hugging Face model card front-matter declares 'license: mit' for the released weights; the source repo LICENSE is also MIT.

https://foldscout.com/tools/esm3/#2026-10-15 2026-10-15T00:00:00Z

MIT License (LICENSE.md, Copyright 2026 Chan Zuckerberg Biohub, Inc.). The repository LICENSE.md is MIT and the README's Licenses section states 'These models are available under the MIT license' - a change from the earlier non-commercial Cambrian open licence. Larger checkpoints remain behind a hosted API; the open ones are the MIT-licensed download.

https://foldscout.com/tools/esmfold/#2026-10-15 2026-10-15T00:00:00Z

MIT License. MIT LICENSE file in the facebookresearch/esm repo covering the released code and models.

https://foldscout.com/tools/evo2/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0. Repo LICENSE is Apache-2.0 and the Hugging Face checkpoints (arcinstitute/evo2_7b and siblings) declare apache-2.0 in their card metadata, so code and weights are both permissive. The published checkpoints are ungated.

https://foldscout.com/tools/evobind/#2026-10-15 2026-10-15T00:00:00Z

unverified - no LICENSE file published in the repository. Checked via the GitHub licence API and the repository root on the date shown: the repo publishes no LICENSE file and the README states no terms, so by default no rights are granted and the position is unverified. It also runs AlphaFold2 parameters (CC BY 4.0) underneath, which are themselves fine for commercial use.

https://foldscout.com/tools/foldseek/#2026-10-15 2026-10-15T00:00:00Z

GNU General Public License v3.0. LICENSE.md in the repo is GPL-3.0. Internal commercial use is allowed, but distributing software that incorporates Foldseek requires releasing the derivative work under GPL-3.0, which matters if you plan to ship a product containing it.

https://foldscout.com/tools/genie2/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0. Apache-2.0 LICENSE in the repo. The README states the repository provides training and inference code 'as well as model weights', released from the same repository, and no separate weight terms are given - so the permissive grant is the only licence in play.

https://foldscout.com/tools/germinal/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0. Apache-2.0 LICENSE file in the repo; permissive, commercial use allowed. Any bundled third-party weights/dependencies should be checked separately.

https://foldscout.com/tools/gnina/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0 (LICENSE.APACHE). The repo's license file LICENSE.APACHE is Apache-2.0, reported by the GitHub license API. Bundled dependencies (e.g. OpenBabel) may carry their own copyleft terms and should be checked before redistribution.

https://foldscout.com/tools/gromacs/#2026-10-15 2026-10-15T00:00:00Z

GNU Lesser General Public License v2.1. The COPYING file in the official GitLab repository is LGPL v2.1. Commercial use is permitted; distributing modified GROMACS libraries triggers LGPL source-sharing obligations.

https://foldscout.com/tools/helixfold3/#2026-10-15 2026-10-15T00:00:00Z

Custom 'Terms of Use Agreement' - non-commercial use only for code and parameters. The helixfold3 LICENSE states the open-source code and derivative works are 'only available for non-commercial use by individuals and non-commercial organizations... or for journalism', and the README repeats that code and model parameters are non-commercial only. The same README says the free version of the HelixFold3 server is non-commercial while 'the paid version offers unrestricted usage, enabling commercial applications' - so commercial use exists, but only as a paid hosted service, not as a self-hosted model.

https://foldscout.com/tools/humatch/#2026-10-15 2026-10-15T00:00:00Z

BSD 3-Clause License. BSD 3-Clause LICENSE file on the repo's master branch; permissive.

https://foldscout.com/tools/igbert-igt5/#2026-10-15 2026-10-15T00:00:00Z

MIT License (as declared on the model cards). Both model repositories declare the MIT licence in their card metadata on Hugging Face, covering the published weights; the models are ungated and download without an access request. Verified against the Hugging Face model API for Exscientia/IgBert and Exscientia/IgT5.

https://foldscout.com/tools/igfold/#2026-10-15 2026-10-15T00:00:00Z

JHU Academic Software License Agreement. LICENSE.md states only a non-exclusive, nontransferable license for non-commercial purposes; 'Commercial use of the Software requires a separately executed written license agreement.' Derivatives are bound by the same non-commercial terms.

https://foldscout.com/tools/iggm/#2026-10-15 2026-10-15T00:00:00Z

MIT License. MIT LICENSE (Copyright 2024, Tencent Inc.) and an unusually direct README statement: 'Our model and code are released under MIT License, and can be freely used for both academic and commercial purposes.' That sentence covers the weights as well as the code, which is rare in this field. Note the same group's tFold is non-commercial - do not assume the licence carries across repos.

https://foldscout.com/tools/iglm/#2026-10-15 2026-10-15T00:00:00Z

JHU Academic Software License Agreement. LICENSE.md is the JHU Academic Software License Agreement, effective only between JHU and 'a non-profit academic or non-profit research institution'. Same pattern as IgFold from the same lab. A company needs a separate agreement with JHU.

https://foldscout.com/tools/immunebuilder/#2026-10-15 2026-10-15T00:00:00Z

BSD 3-Clause License. BSD 3-Clause LICENSE file in the repo; permissive, commercial use allowed.

https://foldscout.com/tools/la-proteina/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0 (code); NVIDIA Open Model License Agreement (weights); separate dataset licence. This repo splits its licences into a LICENSE/ directory: license_code.txt is Apache-2.0, license_weights.txt is the NVIDIA Open Model License Agreement, and license_datasets.txt covers the data. The Open Model License is the permissive one NVIDIA uses to allow commercial use of model outputs and derivatives, in contrast to the plain 'NVIDIA License' on Proteina which is non-commercial - read the conditions (attribution, trustworthy-AI and no-reverse-engineering terms) before shipping.

https://foldscout.com/tools/ligandmpnn/#2026-10-15 2026-10-15T00:00:00Z

MIT License. MIT LICENSE file in the repo; no field-of-use restriction.

https://foldscout.com/tools/mber/#2026-10-15 2026-10-15T00:00:00Z

MIT License. MIT LICENSE file (Copyright 2025 Manifold Bio), and the README's License section repeats MIT. Caveat to check yourself: its download_weights.sh pulls roughly 9 GB of third-party weights (AlphaFold2, NanoBodyBuilder2, ESM-2) whose own terms apply - AlphaFold2 parameters are CC BY 4.0 and the others are permissive, which is why this still reads as a yes.

https://foldscout.com/tools/mmseqs2/#2026-10-15 2026-10-15T00:00:00Z

MIT License. LICENSE.md in the repo is 'The MIT License (MIT)'.

https://foldscout.com/tools/netsolp/#2026-10-15 2026-10-15T00:00:00Z

BSD 3-Clause License. BSD 3-Clause LICENSE file in the repo (Copyright 2021, Technical University of Denmark); permissive.

https://foldscout.com/tools/oas/#2026-10-15 2026-10-15T00:00:00Z

Creative Commons Attribution 4.0 International (CC BY 4.0). The OAS homepage states: 'Please note that the data contained within OAS is available under a CC-BY 4.0 license.'

https://foldscout.com/tools/pymol-open-source/#2026-10-15 2026-10-15T00:00:00Z

Open-Source PyMOL Copyright Notice (custom permissive, MIT/X11-style). The LICENSE file grants permission to use, copy, modify and distribute for any purpose without fee, provided copyright notices are kept; the PyMOL name may not be used in advertising without permission, and derivatives must be plainly distinguished from Schrödinger's PyMOL products. The paid Incentive PyMOL product is separate.

https://foldscout.com/tools/openfold/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0. Apache-2.0 LICENSE file in the repo. The README notes DeepMind's pretrained parameters fall under CC BY 4.0, replacing the earlier CC BY-NC 4.0 terms; OpenFold's own trained weights are distributed with the project.

https://foldscout.com/tools/openmm/#2026-10-15 2026-10-15T00:00:00Z

Mixed: MIT for most of OpenMM, with some parts under LGPL (see Licenses.txt). Licenses.txt states most of OpenMM is under the MIT License while certain portions are under the LGPL (with GPL referenced for those parts). Commercial use is allowed; redistribution of the LGPL portions carries LGPL obligations.

https://foldscout.com/tools/pepmlm/#2026-10-15 2026-10-15T00:00:00Z

Model card declares MIT, but access is gated behind terms that require non-commercial use. A genuine contradiction, read on the date shown: the Hugging Face card for ChatterjeeLab/PepMLM-650M declares license: mit, while the same card's gated-access fields make you tick 'I agree to use this model for non-commercial use ONLY', plus authorship, data-sharing and no-patent conditions. The GitHub repo publishes no LICENSE file at all. Those access terms are what you actually accept to obtain the weights, so treat it as non-commercial until the authors reconcile the two.

https://foldscout.com/tools/prodigy/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0. Apache-2.0 LICENSE file reported by the GitHub license API for haddocking/prodigy.

https://foldscout.com/tools/progen3/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0 (code, LICENSE-CODE); CC BY-NC-SA 4.0 (model weights). The README states up front that 'the model weights are released under a non-commercial usage license', and its LICENSE section splits them: Apache-2.0 for the code in LICENSE-CODE, CC BY-NC-SA 4.0 for the weights. The Hugging Face model card metadata also declares cc-by-nc-sa-4.0. The code being Apache-2.0 does not help: without the weights there is no model.

https://foldscout.com/tools/pdb/#2026-10-15 2026-10-15T00:00:00Z

CC0 1.0 Universal (archive data). The RCSB usage policy page states the wwPDB policy makes PDB archive data files available under CC0 1.0, as is data from RCSB programmatic APIs. RCSB software products are separately under MIT or Apache-2.0.

https://foldscout.com/tools/proteina/#2026-10-15 2026-10-15T00:00:00Z

NVIDIA License (non-commercial). The LICENSE file's section 3.3 'Use Limitation' states the work and any derivative works 'only may be used or intended for use non-commercially', defining non-commercially as 'for research or evaluation purposes only', with an explicit carve-out letting NVIDIA itself use it commercially. Unambiguous: a company cannot use this in product work.

https://foldscout.com/tools/proteinmpnn/#2026-10-15 2026-10-15T00:00:00Z

MIT License. MIT LICENSE file in the repo; no field-of-use restriction.

https://foldscout.com/tools/protenix/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0 (code and released model parameters). The README's License section states the project, code and model parameters, is released under Apache 2.0 and is 'free for both academic research and commercial use'. Important exception read in the same README: the newer Protenix-v2 weights are described as proprietary and confidential, not released under any open-source licence - so the free commercial grant covers the openly released checkpoints, not v2.

https://foldscout.com/tools/protgpt2/#2026-10-15 2026-10-15T00:00:00Z

Apache License 2.0 (as declared on the model card). The Hugging Face model card metadata declares apache-2.0 for the published weights, and the model is ungated. Verified against the Hugging Face model API.

https://foldscout.com/tools/pyrosetta/#2026-10-15 2026-10-15T00:00:00Z

RosettaCommons license (free academic/non-profit; paid commercial). The official licensing page states licensing is free for academic and non-profit institutions and available to commercial users for a fee, handled through Rosetta Commons. A commercial entity needs a paid license.

https://foldscout.com/tools/rfantibody/#2026-10-15 2026-10-15T00:00:00Z

MIT License. The repo LICENSE is MIT, which covers the code. The README downloads model weights via include/download_weights.sh but states no separate license for those weights, so weight terms are unverified.

https://foldscout.com/tools/rfdiffusion/#2026-10-15 2026-10-15T00:00:00Z

BSD License (as titled in the repo LICENSE file). The LICENSE text states it covers both source code and the model weights referenced in the README; it is a permissive BSD-style license with no field-of-use restriction.

https://foldscout.com/tools/rfdiffusion2/#2026-10-15 2026-10-15T00:00:00Z

BSD 3-Clause License (code); no licence stated for the downloaded weights. The repo LICENSE.md is BSD 3-Clause (2025, Institute for Protein Design) and mentions only source and binary forms; the README's setup step downloads large model weight files and containers with no licence statement of their own, so the weights' commercial terms are unverified. The README also marks the release 'under construction'.

https://foldscout.com/tools/sabdab/#2026-10-15 2026-10-15T00:00:00Z

Creative Commons Attribution 4.0 International (CC BY 4.0). The SAbDab site states the data is made available under CC BY 4.0 (link to creativecommons.org/licenses/by/4.0/ in the site's about text); attribution required.

https://foldscout.com/tools/tap/#2026-10-15 2026-10-15T00:00:00Z

unverified. The SAbPred TAP web page states no license or terms of use, and no public source repository license was found; terms for commercial use are therefore unverified.

https://foldscout.com/tools/tfold/#2026-10-15 2026-10-15T00:00:00Z

PolyForm Noncommercial License 1.0.0. The repo LICENSE is PolyForm Noncommercial 1.0.0, which grants rights only for noncommercial purposes. Contrast with the same lab's IgGM, which is MIT and explicitly commercial-friendly - read each repo's own file.

https://foldscout.com/tools/thermompnn/#2026-10-15 2026-10-15T00:00:00Z

MIT License. MIT LICENSE file in the repo.

https://foldscout.com/tools/uniprot/#2026-10-15 2026-10-15T00:00:00Z

Creative Commons Attribution 4.0 International (CC BY 4.0). The UniProt license help page states CC BY 4.0 applies to all copyrightable parts of their databases, with a disclaimer that some data may be covered by patents or other rights.