Humatch
Humanness scoring and humanisation guidance for antibody sequences.
Developer: OPIG, University of Oxford
Overview
- Developer
- OPIG, University of Oxford
- Commercial rights
- Commercial OK
- Commercial cost
- Free commercially
- Compute
- CPU
- Open weights
- Yes
- Last verified
Capabilities
Humanness scoring and humanisation. Input: heavy/light antibody sequences; output: a humanness score per chain plus suggested germline-directed mutations, so you can de-risk a non-human design before ordering it.
When to use it
Use to check how human-like a designed or murine-derived sequence looks before humanisation work. Humanness scores correlate with, but do not measure, clinical immunogenicity.
Input / Output
- Input
- heavy/light antibody sequences
- Output
- a humanness score per chain plus suggested germline-directed mutations, so you can de-risk a non-human design before ordering it
Compute
Commercial Licensing
Commercial rights — may a company use it?
Commercial use OKLicence as writtenBSD 3-Clause License
BSD 3-Clause LICENSE file on the repo's master branch; permissive.
The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.
Commercial cost — is commercial use free of charge?
Free for commercial useNothing to pay: the licence read at the source grants commercial use with no fee, and the code and weights are public downloads. You still pay for your own compute.
Price and rights are separate: this panel is about money, the panel above is about permission.
- Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
- Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
- Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
- Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.
Model Weights
Open weights. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.
Dependencies
Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.
Official References
- Official site / repo
- github.com/oxpig/Humatch
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