Germinal
End-to-end pipeline for de novo nanobody and scFv design.
Developer: Santiago Mille-Fragoso et al. (open-source release)
Overview
- Developer
- Santiago Mille-Fragoso et al. (open-source release)
- Category
- Antibody-specific design
- Commercial rights
- Commercial OK
- Commercial cost
- Free commercially
- Compute
- Heavy GPU
- Open weights
- Unverified
- Last verified
Capabilities
End-to-end de novo nanobody and scFv design. Input: target PDB + epitope residues; output: ranked designed antibody sequences with predicted complexes, by combining backbone hallucination, sequence design and in-silico filtering in one pipeline.
When to use it
Consider for antibody/nanobody design when you want an alternative to RFantibody with a reported wet-lab validated pipeline. Young project; dependency stack is heavy and results are not widely reproduced.
Input / Output
- Input
- target PDB + epitope residues
- Output
- ranked designed antibody sequences with predicted complexes, by combining backbone hallucination, sequence design and in-silico filtering in one pipeline
Compute
Heavy GPU. Other tools with this compute profile →
Commercial Licensing
Commercial rights — may a company use it?
Commercial use OKLicence as writtenApache License 2.0
Apache-2.0 LICENSE file in the repo; permissive, commercial use allowed. Any bundled third-party weights/dependencies should be checked separately.
The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.
Commercial cost — is commercial use free of charge?
Free for commercial useApache-2.0 code, no fee. Check the dependency stack it installs before commercial deployment - the pipeline pulls in several third-party models.
Price and rights are separate: this panel is about money, the panel above is about permission.
- Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
- Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
- Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
- Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.
Model Weights
Weights: unverified. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.
Dependencies
Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.
Official References
- Official site / repo
- github.com/SantiagoMille/germinal
From the makers of FoldScout
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