IgFold

Fast antibody Fv structure prediction from sequence.

Developer: Gray lab, Johns Hopkins University

Not for commercial useNo commercial option at any price

Overview

Developer
Gray lab, Johns Hopkins University
Commercial rights
Non-commercial
Commercial cost
No commercial option
Compute
Single GPU
Open weights
Yes
Last verified

Capabilities

Antibody Fv structure prediction. Input: heavy and light chain sequences; output: an Fv PDB with per-residue error estimates, in under a minute - fast enough for whole design libraries, but the licence is academic-only.

When to use it

Only for academic work: fast Fv models in seconds. For any commercial antibody program use ImmuneBuilder or ABodyBuilder3 instead.

Input / Output

Input
heavy and light chain sequences
Output
an Fv PDB with per-residue error estimates, in under a minute - fast enough for whole design libraries, but the licence is academic-only

Compute

Single GPU. Other tools with this compute profile →

Commercial Licensing

Commercial rights — may a company use it?

Not for commercial use

Licence as writtenJHU Academic Software License Agreement

LICENSE.md states only a non-exclusive, nontransferable license for non-commercial purposes; 'Commercial use of the Software requires a separately executed written license agreement.' Derivatives are bound by the same non-commercial terms.

Original sources — read on 15 Oct 2026
  1. raw.githubusercontent.com/Graylab/IgFold/main/LICENSE.md

The licence limits use to non-commercial purposes; a company needs a separate agreement.

Commercial cost — is commercial use free of charge?

No commercial option at any price

No fee is charged, but no commercial right is granted either: the JHU Academic Software License covers non-profit academic/research institutions only. A company would have to negotiate separately with JHU; no published commercial price exists. ImmuneBuilder or ABodyBuilder3 avoid the problem entirely.

Original sources — read on 15 Oct 2026
  1. raw.githubusercontent.com/Graylab/IgFold/main/LICENSE.md

Price and rights are separate: this panel is about money, the panel above is about permission.

  • Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
  • Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
  • Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
  • Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.

Model Weights

Open weights. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.

Dependencies

Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.

Official References

Official site / repo
github.com/Graylab/IgFold

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