BoltzGen
Generative model for binder design across protein and non-protein targets.
Developer: Boltz team (MIT CSAIL and collaborators)
Overview
- Developer
- Boltz team (MIT CSAIL and collaborators)
- Commercial rights
- Unverified
- Commercial cost
- Free commercially
- Compute
- Heavy GPU
- Open weights
- Yes
- Last verified
Capabilities
Generative binder design against protein and non-protein targets. Input: target (protein, nucleic acid or small molecule) plus binding-site spec in YAML; output: designed binder backbones and sequences with self-consistency/refolding metrics.
When to use it
Reach for it when you want a newer generative binder designer with built-in refolding metrics. Large download (~40 GB with ESMFold2) and needs a recent CUDA driver; very little independent wet-lab replication published yet.
Input / Output
- Input
- target (protein, nucleic acid or small molecule) plus binding-site spec in YAML
- Output
- designed binder backbones and sequences with self-consistency/refolding metrics
Compute
Heavy GPU. Other tools with this compute profile →
Commercial Licensing
Commercial rights — may a company use it?
UnverifiedLicence as writtenMIT License
The repo LICENSE is MIT, covering the code. The README documents automatic download of ~6 GB Boltz weights plus ESMFold2 weights but makes no license statement for those weights, so weight terms are unverified.
We could not find a published statement that settles it (often: the model weights carry no licence). Treat as unknown.
Commercial cost — is commercial use free of charge?
Free for commercial useNo fee: code is MIT and the weights download automatically. The weights' own terms are not published, so 'free' here describes price, not a settled right to use them commercially.
Price and rights are separate: this panel is about money, the panel above is about permission.
- Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
- Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
- Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
- Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.
Model Weights
Open weights. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.
Dependencies
Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.
Official References
- Official site / repo
- github.com/HannesStark/boltzgen
From the makers of FoldScout
From AI Design to Wet-Lab Validation
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- Protein Expression
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- Binding Affinity
- Aggregation Assessment
- Stability Evaluation
- Developability Assessment
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