RFdiffusion2
Atom-level successor to RFdiffusion, aimed at enzyme and motif scaffolding.
Developer: Institute for Protein Design, University of Washington (RosettaCommons)
Overview
- Developer
- Institute for Protein Design, University of Washington (RosettaCommons)
- Commercial rights
- Unverified
- Commercial cost
- Cost unverified
- Compute
- Heavy GPU
- Open weights
- Yes
- Last verified
Capabilities
Generates backbones around an atomic motif without having to specify its indices. Input: a set of catalytic/functional atoms or a target site; output: backbone PDBs scaffolding that geometry, which you then sequence-design (LigandMPNN) and refold. Inference only in this release.
When to use it
Reach for it over RFdiffusion v1 when the design problem is an atom-level site (enzyme active site, metal or ligand geometry) rather than a plain binder. Early release, inference only, and the weight licence question is unresolved - for commercial work that matters.
Input / Output
- Input
- a set of catalytic/functional atoms or a target site
- Output
- backbone PDBs scaffolding that geometry, which you then sequence-design (LigandMPNN) and refold
Compute
Heavy GPU. Other tools with this compute profile →
Commercial Licensing
Commercial rights — may a company use it?
UnverifiedLicence as writtenBSD 3-Clause License (code); no licence stated for the downloaded weights
The repo LICENSE.md is BSD 3-Clause (2025, Institute for Protein Design) and mentions only source and binary forms; the README's setup step downloads large model weight files and containers with no licence statement of their own, so the weights' commercial terms are unverified. The README also marks the release 'under construction'.
We could not find a published statement that settles it (often: the model weights carry no licence). Treat as unknown.
Commercial cost — is commercial use free of charge?
Cost unverifiedNothing is charged for the download. Whether a company may use the weights at all is unsettled, so no price can be stated.
Price and rights are separate: this panel is about money, the panel above is about permission.
- Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
- Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
- Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
- Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.
Model Weights
Open weights. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.
Dependencies
Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.
Official References
- Official site / repo
- github.com/RosettaCommons/RFdiffusion2
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