Proteina
Large flow-matching backbone generator from NVIDIA - research and evaluation only.
Developer: NVIDIA (BioNeMo)
Overview
- Developer
- NVIDIA (BioNeMo)
- Commercial rights
- Non-commercial
- Commercial cost
- No commercial option
- Compute
- Heavy GPU
- Open weights
- Yes
- Last verified
Capabilities
Generates protein backbones at scale, including long chains and fold-class-conditioned samples. Input: length, fold class label or motif; output: backbone structures for downstream sequence design. Trained on a very large synthetic+PDB corpus.
When to use it
Academic benchmarking of backbone generation, or inspiration for scale. For anything commercial, use RFdiffusion or Genie 2 instead - note that NVIDIA's own La-Proteina ships under different, commercially usable weight terms.
Input / Output
- Input
- length, fold class label or motif
- Output
- backbone structures for downstream sequence design
Compute
Heavy GPU. Other tools with this compute profile →
Commercial Licensing
Commercial rights — may a company use it?
Not for commercial useLicence as writtenNVIDIA License (non-commercial)
The LICENSE file's section 3.3 'Use Limitation' states the work and any derivative works 'only may be used or intended for use non-commercially', defining non-commercially as 'for research or evaluation purposes only', with an explicit carve-out letting NVIDIA itself use it commercially. Unambiguous: a company cannot use this in product work.
The licence limits use to non-commercial purposes; a company needs a separate agreement.
Commercial cost — is commercial use free of charge?
No commercial option at any priceNo commercial option exists at any price: the licence limits use to research or evaluation and NVIDIA publishes no commercial licence for it.
Price and rights are separate: this panel is about money, the panel above is about permission.
- Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
- Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
- Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
- Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.
Model Weights
Open weights. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.
Dependencies
Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.
Official References
- Official site / repo
- github.com/NVIDIA-BioNeMo/proteina
From the makers of FoldScout
From AI Design to Wet-Lab Validation
Designed a promising protein or antibody? Seq2Study helps translate AI-generated sequences into experimental data.
- Protein Expression
- Protein Purification
- Binding Affinity
- Aggregation Assessment
- Stability Evaluation
- Developability Assessment
Get told when a licence changes
Licences on these tools do change. One short email when a status flips or a tool is added. No other use of your address.